Scientific Evidence
Research shows that personally-relevant content produces
stronger brain engagement than generic content.
EngagedSenior by MemoryCo™ is built on this principle — our platform lets communities personalize
games and activities with their own content, supporting cognitive health
and meaningful interaction among residents.
This is why organizations adopting EngagedSenior see higher participation and sustained engagement compared to generic activity programs. Below are relevant scientific articles from our founders and collaborators:
This is why organizations adopting EngagedSenior see higher participation and sustained engagement compared to generic activity programs. Below are relevant scientific articles from our founders and collaborators:
Playing video games for four weeks can improve hippocampal-based memory in a population that is already experiencing age-related decline in memory:
Clemenson GD, et al. (2020) Enriching hippocampal memory function in older adults through video games. Behav Brain Res. 390:112667.
Clemenson GD, et al. (2020) Enriching hippocampal memory function in older adults through video games. Behav Brain Res. 390:112667.
Adopting new technologies have the potential to reduce or delay cognitive changes associated with ageing:
Vaportzis, E., Martin, M., & Gow, A. J. (2017). A tablet for healthy ageing: the effect of a tablet computer training intervention on cognitive abilities in older adults. The American Journal of Geriatric Psychiatry, 25(8), 841-851.
Vaportzis, E., Martin, M., & Gow, A. J. (2017). A tablet for healthy ageing: the effect of a tablet computer training intervention on cognitive abilities in older adults. The American Journal of Geriatric Psychiatry, 25(8), 841-851.
Participation in cognitive activities pertinent to game playing may help prevent Alzheimer's by preserving brain structures and cognitive functions:
Schultz, S. A., et al. (2015). Participation in cognitively-stimulating activities is associated with brain structure and cognitive function in preclinical Alzheimer’s disease. Brain imaging and behavior, 9(4), 729-736.
Schultz, S. A., et al. (2015). Participation in cognitively-stimulating activities is associated with brain structure and cognitive function in preclinical Alzheimer’s disease. Brain imaging and behavior, 9(4), 729-736.
Being mentally active helps fend off cognitive impairments, underlining the importance of MemoryCo™ games and activities:
Janina Krell-Roesch et al. (2019). Quantity and quality of mental activities and the risk of incident mild cognitive impairment. Neurology 93(6), e548-e558.
Janina Krell-Roesch et al. (2019). Quantity and quality of mental activities and the risk of incident mild cognitive impairment. Neurology 93(6), e548-e558.
The importance of personally-relevant information in memory recall:
Renoult, L., et al. (2016). Personal semantics: Is it distinct from episodic and semantic memory? An electrophysiological study of memory for autobiographical facts and repeated events. Neuropsychologia, 83, 242-256.
Renoult, L., et al. (2016). Personal semantics: Is it distinct from episodic and semantic memory? An electrophysiological study of memory for autobiographical facts and repeated events. Neuropsychologia, 83, 242-256.
Brain activity is increased when personally-relevant images and content are shown--which is central to MemoryCo™'s approach:
Viskontas, I. V., Quiroga, R. Q., & Fried, I. (2009). Human medial temporal lobe neurons respond preferentially to personally relevant images. Proceedings of the National Academy of Sciences, 106(50), 21329-21334.
Viskontas, I. V., Quiroga, R. Q., & Fried, I. (2009). Human medial temporal lobe neurons respond preferentially to personally relevant images. Proceedings of the National Academy of Sciences, 106(50), 21329-21334.
Personally-relevant memories are in brain regions targeted by the MemoryCo™ games and activities:
Okuyama, T., Kitamura, T., Roy, D. S., Itohara, S., & Tonegawa, S. (2016). Ventral CA1 neurons store social memory. Science, 353(6307), 1536-1541.
Okuyama, T., Kitamura, T., Roy, D. S., Itohara, S., & Tonegawa, S. (2016). Ventral CA1 neurons store social memory. Science, 353(6307), 1536-1541.
The importance of MemoryCo™'s personally-relevant content in the grand context of memory:
Renoult, L., et al. (2012). Personal semantics: at the crossroads of semantic and episodic memory. Trends in cognitive sciences, 16(11), 550-558.
Renoult, L., et al. (2012). Personal semantics: at the crossroads of semantic and episodic memory. Trends in cognitive sciences, 16(11), 550-558.
This article is a summary from over a decade of findings highlighting the importance of personally-relevant information in memory performance:
Suthana, N., & Fried, I. (2012). Percepts to recollections: insights from single neuron recordings in the human brain. Trends in cognitive sciences, 16(8), 427-436.
Suthana, N., & Fried, I. (2012). Percepts to recollections: insights from single neuron recordings in the human brain. Trends in cognitive sciences, 16(8), 427-436.
This study shows that improving brain activity, as applied by MemoryCo™, leads to better memory performance:
Titiz, A., Hill, M. R., Mankin, E. A., Aghajan, Z. M., Eliashiv, D., Tchemodanov, N., ... & Behnke, E. (2017). Theta-burst microstimulation in the human entorhinal area improves memory specificity. Elife, 6, e29515.
Titiz, A., Hill, M. R., Mankin, E. A., Aghajan, Z. M., Eliashiv, D., Tchemodanov, N., ... & Behnke, E. (2017). Theta-burst microstimulation in the human entorhinal area improves memory specificity. Elife, 6, e29515.
This study shows
the relationship between sleep and memory in the context of neurological disorders:
Titiz, A., Mahoney, J. M., Testorf, M. E., Holmes, G. L., & Scott, R. C. (2014). Cognitive impairment in temporal lobe epilepsy: role of online and offline processing of single cell information. Hippocampus, 24(9), 1129-1145.
Titiz, A., Mahoney, J. M., Testorf, M. E., Holmes, G. L., & Scott, R. C. (2014). Cognitive impairment in temporal lobe epilepsy: role of online and offline processing of single cell information. Hippocampus, 24(9), 1129-1145.
This study shows
the importance of the pacing of cognitive tasks to optimize learning:
Richard, G. R., Titiz, A., Tyler, A., Holmes, G. L., Scott, R. C., & Lenck‐Santini, P. P. (2013). Speed modulation of hippocampal theta frequency correlates with spatial memory performance. Hippocampus, 23(12), 1269-1279.
Richard, G. R., Titiz, A., Tyler, A., Holmes, G. L., Scott, R. C., & Lenck‐Santini, P. P. (2013). Speed modulation of hippocampal theta frequency correlates with spatial memory performance. Hippocampus, 23(12), 1269-1279.